This game is about 60% the length of Human Rev, and offers pretty much the same challenges, with very little new situational additions.
The best way to prepare you for this is playing Deus Ex: Human Revolution. Make sure to save often if you want to redo or undo choices. Check out guides on the 'Pacifist' & 'Foxiest of the Hounds' Achievement if you want more details and walkthroughs relating to the non-lethal option. Choose which you think is best for you, and then make your way through missions by taking the alternate paths, usually consisting of vents or tunnels in less obvious locations. The Tranq Rifle is the more expensive/rare of the two, but it has the shortfall of taking time to affect it's target. To do this I suggest picking the non-lethal option at the start of the game, to get the Tranquilizer Rifle or Stun-gun, which will complement your Takedown ability (tap ). The easiest way to beat the gameplay portions of the game is to go non-lethal on Give Me a Story.
You can beat this game in a variety of different ways.